When I commercial fished there were two captains. WWII veterans. Lefty, one arm and Shorty, one leg gone above the knee and one gone below. They liked the life and adapted. I had many of my bones from the lower back to my feet broken, I have pain, and I'm 69, but like my boating life, so I adapt.
If your wife wants the life then you can make it work. If your talking her into it and If she's doing it to please you, it probably won't work.
One hint - a big comfortable boat is easier to live in with disabilities than a smaller boat with tight spaces and steep stairs.