KJ, one of the most beautiful parts of the ICW is the Waccamaw River just below Government Cut behind Myrtle Beach. I love the seclusion and anchoring in the narrow channels with moss draped Cypress trees on both sides. Sometimes even an old alligator will cruise by. Lots of night sounds.
Stop at Bucksport for home made sausage. Then George Town for a nice nights stay. There is a new fuel stop, and sometimes you can buy clams if you go up the channel to McClellansville. Isle of Palms Marina has a decent restaurant. If you haven't stayed there, Charleston City Marina with its Mega Dock is convenient and one of the most interesting and best run marinas on the coast. Lots to see and do. They have a courtesy van that will take and pick up at the historic district, Harris Teeters Supermarket, or West Marine. It is not something I would want to miss.
Take your time, and enjoy life along the ICW. Moonstruck cruises fast, but we use that speed to have more time for stopping along the way. If you haven't been cruising the SC and GA marshes, it is an acquired taste. Once acquired, the beauty and wild life along with the seclusion is awesome. Watch out for green head flies and other insects. They are necessary to deter yankees from staying too long in the South.
There are many marinas in the area on both sides of the harbor. You can check out the WATERWAY GUIDE or ACTIVE CAPTAIN along with Skipper Bob's book of anchorages. If you haven't joined activecaptain.com, I suggest that you do. Great info.
Probably more than you wanted to know, but you can tell I love the whole ICW.
Forgot to mention offshore conditions. I would think 2-3' seas about 9 second duration would be the limit I would want in your boat. That would usually be about 10 knots of wind.