This could get really, really ugly for Florida. Normally a storm hits the east coast at an angle and the damage is limited to the diameter of the storm. Winds diminish substantially as you go out from the center, and are considerably less on the southwest side of the eye. Once the eye is over land, it weakens further.
This storm could make landfall right on the tip of the Florida Pennisula and travel right up middle of the state. There is no elevation in FL to interupt the motion, and the bottom third of the state is all swamp land so the storm could still build or maintain strength from the warm water of the Everglades. That would put the most damaging quadrant of the storm right over the huge population centers of Miami, Ft Lauderdale, Delray, and West Palm. I don't think that's ever happened before but the potential for loss here could be bigger than Andrew. I know this is the worst case scenario out of many, and lots can change over the next week, but ...the potential is there.