I would check the documentation that came with your software and see if the have any recommended/approved devices. I have used an Actisense NGT-1 with Coastal Explorer and at one time you had to download a special “plug-in” so that the software would look at the USB port for NMEA data. I haven’t used it in quite a few years after switching to the NEMO, so I am not sure if the plug-in is still required.
One clarification, the navigation program is not really sending the route to the autopilot, it is sending waypoints and other NMEA 2000 data the autopilot needs in order to follow the desired course. The autopilot is getting a series of waypoints from the navigation program but basically one at a time.
Tom