I don't want to sound to negative but why a twin engine semi displacement cruiser with so much glass and small fuel tanks.
Voyage wise I would probably come via Hawaii and down shortens up the legs and is more power boat friendly so I am led to believe.
Changing props at sea, would appear to be fraught with difficulty.
Otherwise yeah go for it , use a bladder or two for fuel and not drums, easier to carry when empty and the load is spread more evenly , stow more efficiently and don't cause any damage when moving around. (You weren't thinking of dumping the MT drums at sea were you)
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