It will most certainly need to be bled because the lifter pump and supply line will be lose much of their fluid and become filled with air. The discharge line will also lose its fuel if disconnected. If it isn't bled this will all get pushed into the pump and past the pump into the injectors, etc.
Also, before I forget, make sure you shut off the fuel before disconnecting the line(s).
If you want to make things a little faster, and if your tanks are above the lifter and will gravity drain to it, open the valve before tightening down the supply line to the pump and let the fuel gravity drain to the pumpcand out the loose connection (have rags ready). When it comes gushing out, tighten it until it stops and clean up. If you don't want that mess, skip it and just tighten the connections. You may just end up bleeding more.
Loosen the bleeder screw on the injector pump. I've marked it on two pictures. Note that one of them has the tag upside down. The screw is just left and above the tag (tag right side up or upside down!). Set up some rags there. Open the fuel valve.
Pump the lifter pump and keep pumping. It can be a couple hundred pumps. Initially it'll feel really soft. That is pushing only compressible air. As it gets fuel to it, it becomes firmer
Initially, it is inconsistent as it gets a mix of air and fuel, then it gets consistent. The fuel will start to spit a bit out of the bleeder, then fommfor a long while. Then get to be pure fuel with no air. Don't rush this. Get all of the air out and then some. Once it is bled, tighten the bleeder. You are done.
If you have an inline bleeder, use it instead of pumping by hand, but otherwise do the same thing.
I know the manual points to two different bleeders on the pump and then instructs to bleed the injectors. Bleeding thebinjectors requires turning the engine over to spin the pump. There is no need. None. Just bleed the pump well at that one bleeder and you are done. Really.
There will still be some air in there, but it is fine. Start the engine. The first few turns will push the air into and out of the injectors into the return and eventually into your fuel tank where it makes up for some fuel going into the tank with mess vent air coming in by a hair. Then the engine will start. For just a few seconds, the rpms will be a bit unsteady and there will be a bit of white fuel smoke. This is just do to an unsteady fuel flow and uneven fuel pressure while it clears the rest of the air. In just a few seconds it'll run as nice and smooth as ever. All good.
You can start cracking injectors and bleeding them by turning over the engjne, but it'll change little. You still won't get all the air out. If you do it anyway, have some more copper crush washers for the injector returns handy. Eventually one (or more) will have been recrushed one too many times and will develop a leak and need replaced. Again, just don't bother. No good comes from it. It decreases the smoke and unsteady phase a bit, but it is more work and can need crush washers or leak. Not worth it.
If you go a couple hundred pumps by hand and aren't getting any fuel or resistance, double check your valve, then tap the starter and go for a couple hundred more. It is unlikely, but there is an engine rotation where the pumping can be problematic.
Hope this helps.