We did the
Down East Loop and those areas were actually far less "remote" than they appeared. There are recreational marinas at reasonable distances. The link above is the blog I created along the loop back in 2016.
Before that, we crossed the Bay of Fundy in our 28' gas-powered express cruiser. Fuel certainly was a concern, since we had about a 100NM range. We brought four, six-gallon gas cans, and a couple of times had to get a ride into town to fill them. People were always offering to help, and it really turned out to be easier than I thought it would. But it did convince me that my next boat would be a diesel, and have a much longer range!