Two comments, one on each recent point, both from experience, one bitter, one good.
FF is right in that most macerator pumps which allegedly will self-prime to at least a metre, in fact don't - not if left for any time in my experience anyway. My TMC was suposed to do so, and is only mounted about a foot above the outlet from my holding tank, but unless used very recently I have to prime it by routing some water back down the outlet to the pump first, before it will pump out.
The second point is to support Daddyo re the virtues of bottom take-off of fuel lines from tank. Yes, the constant shaking up and the fact any dirt or water is sucked out constantly means it just does not accumulate. How do I know? Well, I often commit the sin of only having my tanks half full, (or less, as diesel is dear here ($Aus 1.50 a litre = $US6 per US gal), and even so, I rarely drain more than a teaspoonful of water from the separator in the primary filter, and I have only changed the actual filters once in 7 yrs, because each time I check them they look too clean, and I'm very much an "if it ain't broke don't fix it kinda guy. The engine has never missed a beat in all that time. Do we have cleaner diesel here in Oz than you in the US - I think not...?