On a typical diesel duck (38 to 41ft range) there is the stern cabin with double berth and the bow cabin with galley/dinette and head. The proposal is placing the galley/dinette/saloon in the stern cabin and the head followed by V-berth up in the bow.
In calm weather either arrangement works fine, but for a cruising couple in rough weather:
1) The bow cabin is either unusable or at minimum quite uncomfortable;
2) Galley forward means that preparing proper meals is difficult which leads to risk of fatigue and health issues on long hauls;
3) Galley in the stern cabin, with a long settee, provides a sea berth since the other person is in the pilothouse.
A passage maker needs to be designed/built for safety in rough conditions, but in reality the majority of one's time onboard is at anchor or local cruising with very little time (percentage wise) being spent in rough or storm conditions. It's all a compromise of course.