We have been across several times we usually leave Apalachicola for Anclote key off of Tarpon Springs.
In our previous boat a Camano 31 we did Apalachicola to Carabelle, across to Steihatchee, down to Crystal River, to Tarpon Springs and on South to Sanibel with many stops along the way. Coming back We stopped in Cedar Key, Steenhatchee to Apalachicola. We have not been to Swanee River, St Marks or Panacea. We did enjoy the stop in Crystal River very much. I am sorry to say we would probably not bother stopping at Carabelle, Cedar Key, or Steinhatchee again. Not that we disliked them but they were not very interesting and are a long way in through shallow water. The channels were well marked but there are many other places we would rather spend time either west of Carabelle, or south of Anclote Tarpon Springs is a favorite stop.