I'm solo almost always. There are some challenges. Most are relative to circumstance or conditions. Simply, many of the problems you will face can be overcome by not going that day or going to plan B. As an example, most any competent captain should be able to dock their boat in most slips, during daylight hours, without current, wind or boat traffic. When you start adding these challenges, it becomes more difficult and maybe impossible. So, you don't go on days when weather is expected to be bad or deteriorate. You have to be able to say no I'm not going to try docking now because of the tidal currents, the wind or boat traffic in the fairways. You have to be able to refuse a slip assignment because it's beyond your ability to get the boat safely in it. You need to have plan B that says if the marina doesn't work out, I can drop a hook over here, and be safe for the night. The last one speaks to having alternatives before you start in the morning.
There are some things that will require practice solo, or changing technique. Locking and docking are two of these things that will only be mastered with lots of practice. Develop your techniques and practice them solo while your wife is there to catch you when you're still learning.
If you have specific questions, don't hesitate to ask. I did the Great Loop solo, so much of what you will face, I have some experience with.
Ted