I kept my boat on Lake Erie for many years, the main thing to watch out for are fish nets which are often stretched out over great distances. They are generally well marked but difficult to see at night or stormy weather. If you look at the string of floats you will see entrance/exits that allow you to pass through the nets negating the need to go around.
Watch the weather, the bottom of the lake is littered with ships and is a sober reminder of the vulnerability of our little boats and unpredictability of the lake. Erie is shallow and builds very steep short frequency waves. The Pelee Passage with its strong current in an opposing wind can be brutal. Also keep in mind there are precious few anchorages but there are ports nearly every 50 miles along both coasts. Careful not to cut corners going around Point Pelee, shallow and rocky extending miles off shore.
That said, mostly it is tame and navigating at night is not a problem but watch for the nets. If you can, set aside some time to explore there are many quaint ports to visit and explore on both the cannuck side & the US side. Vermillion is a must see, as is Port Dover but there are countless others.
Take your time, enjoy your trip.